| Protein name |
Beta-lactoglobulin |
| Host compatibility |
Komagatella phaffi (Pichia pastoris) |
| Yield |
>1 g/L (Kim et al., 1997)
|
| Scale (in specific example) |
Lab scale in bioreactor (Kim et al., 1997)
|
| Biggest scale product has been develloped in this organism |
Industrial (Remilk)
|
| Regulatory status in Europe |
Not allowed |
| Regulatory status in other parts of the world |
|
| Companies producing this protein in this organism |
|
| Extra/remark |
|
| Publications/references |
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Kim, T. R., Goto, Y., Hirota, N., Kuwata, K., Denton, H., Wu, S. Y., Sawyer, L., & Batt, C. A. (1997). High-level expression of bovine beta-lactoglobulin in Pichia pastoris and characterization of its physical properties. Protein Engineering Design and Selection, 10(11), 1339–1345. https://doi.org/10.1093/protein/10.11.1339
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Pandya, R., Gandhi, P., Ji, S., Beauchamp, D., Hom, L., & Inc, P. D. (2018, March). US9924728B2 - Food compositions comprising one or both of recombinant beta-lactoglobulin protein and recombinant alpha-lactalbumin protein - Google Patents. https://patents.google.com/patent/US9924728B2/en
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Kossmann, H., Karslioglu, Ö. Ö., & Breunig, P. (2025). From Moo to Microbes: pathways for precision fermentation in recombinant protein production. Journal of Agriculture and Food Research, 102056. https://doi.org/10.1016/j.jafr.2025.102056
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Keppler, J. K., Heyse, A., Scheidler, E., Uttinger, M. J., Fitzner, L., Jandt, U., Heyn, T. R., Lautenbach, V., Loch, J. I., Lohr, J., Kieserling, H., Günther, G., Kempf, E., Grosch, J., Lewiński, K., Jahn, D., Lübbert, C., Peukert, W., Kulozik, U., . . . Biedendieck, R. (2021). Towards recombinantly produced milk proteins: Physicochemical and emulsifying properties of engineered whey protein beta-lactoglobulin variants. Food Hydrocolloids, 110, 106132. https://doi.org/10.1016/j.foodhyd.2020.106132
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Hoppenreijs, L. J. G., Brune, S. E., Biedendieck, R., Krull, R., Boom, R. M., & Keppler, J. K. (2024). Exploring Functionality Gain for (Recombinant) β-Lactoglobulin Through Production and Processing Interventions. Food and Bioprocess Technology, 17(12), 4897–4914. https://doi.org/10.1007/s11947-024-03414-z
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Chatel, J., Bernard, H., Clement, G., Frobert, Y., Batt, C. A., Gavalchin, J., Peltre, G., & Wal, J. (1996). Expression, purification and immunochemical characterization of recombinant bovine beta-lactoglobulin, a major cow milk allergen. Molecular Immunology, 33(14), 1113–1118. https://doi.org/10.1016/s0161-5890(96)00070-3
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